You ask how is Amanda Ripley involved?  Since we know nothing about her, it seems easy to explore that character.

There was a feeling that Ripley’s daughter was untouchable.  Some people asked the question, “Why wouldn’t have Weyland-Yutani informed Ripley about her daughter’s adventures when she awoke?”

Speaking with Kitguru, Alien: Isolation community manager, Nee N broke it down:

“The game is set fifteen years after the events of Alien, and Amanda has grown up, always wondering what has happened to her mother. She’s currently working for Weyland-Yutani and is approached by an employee of the company, Samuels, to say that they‘ve found the black box flight recorder, ejected from the Nostromo in the moments before its destruction.”

Nee stated: “It’s on a station called Sevastopol and Samuels offers Amanda the chance to go with them and to unlock the secret of what happened to her mother.”

Will get a release later this year.